α1‐Adrenergic receptor (α1‐AR) subtypes: Involvement in regulation of supraoptic nucleus (SON) vasopressin (VP) and oxytocin (OT) neurons
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چکیده
منابع مشابه
Vasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus.
Magnocellular neurons of the supraoptic nucleus release the neuropeptides oxytocin and vasopressin from their dendrites to regulate their synaptic inputs. This study aims to determine the cellular mechanism by which vasopressin modulates excitatory synaptic transmission. Presumably by electroporation through perforated patch, we were able to successfully introduce biocytin into cells in which w...
متن کاملChanges in the electrical properties of supraoptic nucleus oxytocin and vasopressin neurons during lactation.
Magnocellular oxytocin (OT) and vasopressin (VP) neurons adopt different firing patterns in response to relevant physiological stimuli. OT neurons selectively display short (2-4 sec), high-frequency bursts of action potentials that are highly synchronized and correlated with OT release during lactation. The present experiments were done to determine whether the electrophysiological properties o...
متن کامل25 Oxytocin and Vasopressin: Genetics and Behavioral Implications
Oxytocin (OT) and vasopressin (VP) can profoundly affect animal physiology and behavior. Over the past 20 years, the genes that encode OT and VP, as well as their respective receptors, have been identified and intensively studied leading to a greater understanding of the hormones’ functions. The use of transgenic animals, including knockout mice, and viral vectors have opened new vistas of rese...
متن کاملCirculating secretin activates supraoptic nucleus oxytocin and vasopressin neurons via noradrenergic pathways in the rat.
Secretin is a 27-amino acid brain-gut peptide from duodenal S-cells. We tested the effects of systemic administration of secretin to simulate its postprandial release on neuroendocrine neurons of the supraoptic nucleus (SON) in urethane-anesthetized female rats. Secretin dose-dependently increased the firing rate of oxytocin neurons, more potently than cholecystokinin, and dose-dependently incr...
متن کاملCALL FOR PAPERS Integrative and Translational Physiology: Integrative Aspects of Energy Homeostasis and Metabolic Diseases Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors
Song Z, Levin BE, Stevens W, Sladek CD. Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors. Am J Physiol Regul Integr Comp Physiol 306: R447–R456, 2014. First published January 29, 2014; doi:10.1152/ajpregu.00520.2013.— Neurons in the supraoptic nuclei (SON) produce oxytocin and vasopressin and express insulin receptors (InsR) and glucokinase. Since oxytocin i...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.993.5